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Synthesis, molecular docking and biological evaluation of 2,4 disubstituted quinazolines with multi-target activities as anti-cancer and antimicrobial agents
Citations:
3
References:
30
Abstract
A series of 2,4-disubstituted quinazoline derivatives was designed and synthesized as multi-target therapeutic agents that may act as anti-cancer and antimicrobial agents. The target compounds were evaluated for primary anti-cancer activity followed by EGFR inhibition assay for most potent compounds. Compounds 6 and 8c exhibited good EGFR inhibition activity with IC50 values of 0.201 and 0.405 µM,...
Keywords
Sustainable Development Goals (SDG)
2020
Article
Open Access
2-Y Citation Average
0.712
Language
Country
Synthesis, molecular docking and biological evaluation of 2,4 disubstituted quinazolines with multi-target activities as anti-cancer and antimicrobial agents
Citations:
3
References:
30
Abstract
A series of 2,4-disubstituted quinazoline derivatives was designed and synthesized as multi-target therapeutic agents that may act as anti-cancer and antimicrobial agents. The target compounds were evaluated for primary anti-cancer activity followed by EGFR inhibition assay for most potent compounds. Compounds 6 and 8c exhibited good EGFR inhibition activity with IC50 values of 0.201 and 0.405 µM,...
Keywords
Sustainable Development Goals (SDG)
2020
Article
Open Access
2-Y Citation Average
0.712
Language
Country