S YNTHESIS of some new Aryl-azopyridone analogues was synthesized through coupling of diverse Diazonium salts with 1-ethyl-4-methyl-2,6-dioxopiperidine-3-carbonitrile.The proper structures for all incorporated derivatives were demonstrated to be confirmed via various physical and spectral analyses performed.The synthesized analogues were probed as cytotoxic agents toward four dissimilar cell lines...