Due to the biological significance of 1,3,4-oxadiazoles this work is concerned with the synthesis and reactions of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine 1. The parent oxadiazole 1 was obtained from reaction of 4-chlorophenylacetic acid with semicarbazide in the presence of phosphorus oxychloride followed by addition of potassium hydroxide. Acylation of amino oxadiazoles 1 with acid chlori...