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Synthesis and characterization of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine derivatives

Abstract
Due to the biological significance of 1,3,4-oxadiazoles this work is concerned with the synthesis and reactions of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine 1. The parent oxadiazole 1 was obtained from reaction of 4-chlorophenylacetic acid with semicarbazide in the presence of phosphorus oxychloride followed by addition of potassium hydroxide. Acylation of amino oxadiazoles 1 with acid chlori...
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Keywords
Chemistry
Chloroacetyl chloride
Triethylamine
Acetyl chloride
Benzoyl chloride
Chloride
Organic chemistry
Acylation
Oxadiazole
Amine gas treating
Medicinal chemistry
Acetamide
Isocyanate
Potassium hydroxide
Semicarbazide
Catalysis
Polyurethane
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file

Synthesis and characterization of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine derivatives
pdf file

Synthesis and characterization of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine derivatives

Abstract
Due to the biological significance of 1,3,4-oxadiazoles this work is concerned with the synthesis and reactions of new 5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-amine 1. The parent oxadiazole 1 was obtained from reaction of 4-chlorophenylacetic acid with semicarbazide in the presence of phosphorus oxychloride followed by addition of potassium hydroxide. Acylation of amino oxadiazoles 1 with acid chlori...
View PDF
Keywords
Chemistry
Chloroacetyl chloride
Triethylamine
Acetyl chloride
Benzoyl chloride
Chloride
Organic chemistry
Acylation
Oxadiazole
Amine gas treating
Medicinal chemistry
Acetamide
Isocyanate
Potassium hydroxide
Semicarbazide
Catalysis
Polyurethane
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file