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A comparative validation study of Cefprozil diastereoisomers determination in human plasma by HPLC-MS/MS and HPLC-UV methods: application to bioequivalence pilot study

Abstract
A SIMPLE, sensitive and reliable HPLC-MS/MS and HPLC-UV methods were developed and validated for Cis-and Trans-Cefprozil diastereoisomers determination in human plasma.The plasma samples subjected to protein precipitation after the addition of cephalexin as internal standard.Chromatographic separation was achieved using Waters Xbridge C18 column 5µm, 4.6×150mm maintained at 25° C. The HPLC-MS/MS m...
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Keywords
Bioequivalence
High-performance liquid chromatography
Chromatography
Diastereomer
Chemistry
Human plasma
Pharmacokinetics
Pharmacology
Medicine
Organic chemistry
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file

A comparative validation study of Cefprozil diastereoisomers determination in human plasma by HPLC-MS/MS and HPLC-UV methods: application to bioequivalence pilot study
pdf file

A comparative validation study of Cefprozil diastereoisomers determination in human plasma by HPLC-MS/MS and HPLC-UV methods: application to bioequivalence pilot study

Abstract
A SIMPLE, sensitive and reliable HPLC-MS/MS and HPLC-UV methods were developed and validated for Cis-and Trans-Cefprozil diastereoisomers determination in human plasma.The plasma samples subjected to protein precipitation after the addition of cephalexin as internal standard.Chromatographic separation was achieved using Waters Xbridge C18 column 5µm, 4.6×150mm maintained at 25° C. The HPLC-MS/MS m...
View PDF
Keywords
Bioequivalence
High-performance liquid chromatography
Chromatography
Diastereomer
Chemistry
Human plasma
Pharmacokinetics
Pharmacology
Medicine
Organic chemistry
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file