A SIMPLE, sensitive and reliable HPLC-MS/MS and HPLC-UV methods were developed and validated for Cis-and Trans-Cefprozil diastereoisomers determination in human plasma.The plasma samples subjected to protein precipitation after the addition of cephalexin as internal standard.Chromatographic separation was achieved using Waters Xbridge C18 column 5µm, 4.6×150mm maintained at 25° C. The HPLC-MS/MS m...