Background: Osteoarthritis (OA) is the most common age-related joint degenerative disease, which is associated with post menopausal females.Aim of Work: To compare the effect of hormonal replacement therapy (HRT) (Oestrogen and Progesterone) versus calcitonin administration on articular cartilage of the knee joints in murine model of osteoarthritis induced by ovariectomy.Materials and Methods: Thi...