The interplay between the potential toxicity of inhaled volatile organic compounds and polycyclic aromatic hydrocarbons with detoxifying glutathione S-transferase and cytochrome peroxidase genes

Egyptian Journal of Chemistry

Safaa Elserougy, Safia Beshir, Weam Shaheen, Elham Mostafa, Amira N. Ahmed, Atef Mohamed Fathy Mohammed, Safa Nabil Abd El-Fattah, Mona Hamed Ibrahim

Abstract

Background: Volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) stemming from research labs represent potential threats to public health. Aim: This study aimed to identify the profile of organic air pollutants (VOCs and PAH) in research laboratories and the diversity of genetic polymorphism of detoxification enzymes (GSTP1, GSTM1, GSTT1, and CYP2E1) as well as serum immun...

Keywords

Glutathione S-transferase

Peroxidase

Chemistry

Cytochrome P450

Toxicity

Glutathione

Environmental chemistry

Biochemistry

Organic chemistry

Enzyme

2025

Article

Institution

National Research Centre, Clinical and Chemical Pathology Dept., Medical Research and Clinical Studies Institute, Centre of Excellence, Cairo, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2025.351936.11153

Language

en

Country