The solubility is one of the vital parameters to attain the specified concentration of the drug in circulation for the desired (anticipated) pharmacologic response. This work aimed to calculate ion-solvent interaction, the density of ethanol-water (EtOH-H2O) mixtures; the density of oxytetracycline (OTC) saturated solutions, different volumes of solvation (Van der Waals volume, molar volume and el...