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Triazole-Based Schiff Base Metal Complexes: Synthesis, Characterization, Computational Studies and Biomedical Activity Against Cancer, H. pylori, and COVID-19

Abstract
This investigation presents a comprehensive analysis of transition metal complexes formed from a novel Triazole Schiff Base Ligand, (E)-2-(2-(1-(1H-benzo[d][1,2,3]triazol-1-yl)propan-2-ylidene)hydrazineyl)-2-oxoacetamide (OXO). High-yield syntheses produced Cr(III), Co(II), Cu(II), and Cd(II) complexes, characterized as non-electrolytic with 1:1 metal-ligand stoichiometry. DFT calculations using L...
Keywords
Schiff base
Chemistry
Octahedral molecular geometry
Ligand (biochemistry)
HOMO/LUMO
Docking (animal)
Crystallography
Square pyramidal molecular geometry
Stereochemistry
Metal
Molecule
Crystal structure
Organic chemistry
Medicine
Biochemistry
Receptor
Nursing
Sustainable Development Goals (SDG)
Good health and well-being

2024
Article


Triazole-Based Schiff Base Metal Complexes: Synthesis, Characterization, Computational Studies and Biomedical Activity Against Cancer, H. pylori, and COVID-19

Triazole-Based Schiff Base Metal Complexes: Synthesis, Characterization, Computational Studies and Biomedical Activity Against Cancer, H. pylori, and COVID-19

Abstract
This investigation presents a comprehensive analysis of transition metal complexes formed from a novel Triazole Schiff Base Ligand, (E)-2-(2-(1-(1H-benzo[d][1,2,3]triazol-1-yl)propan-2-ylidene)hydrazineyl)-2-oxoacetamide (OXO). High-yield syntheses produced Cr(III), Co(II), Cu(II), and Cd(II) complexes, characterized as non-electrolytic with 1:1 metal-ligand stoichiometry. DFT calculations using L...
Keywords
Schiff base
Chemistry
Octahedral molecular geometry
Ligand (biochemistry)
HOMO/LUMO
Docking (animal)
Crystallography
Square pyramidal molecular geometry
Stereochemistry
Metal
Molecule
Crystal structure
Organic chemistry
Medicine
Biochemistry
Receptor
Nursing
Sustainable Development Goals (SDG)
Good health and well-being

2024
Article