A Novel Controlled Release Subcutaneous Implant of Tramadol Hydrochloride: In Vivo Bioavailability and Neurochemical Study

Shaimaa A. elshebiney, Asmaa F. Galal, Hanan Beheri, Mostafa Mabrouk

Abstract

The current study investigated the pharmacokinetic profile of a newly developed biodegradable subcutaneous tramadol implant and shed some light on neurochemical changes. Ribbons of polycaprolactone polymer were loaded with tramadol HCl in two quantities (T350, T650) and implanted in back skin of rats. Plasma tramadol levels were monitored for 45 days and pharmacokinetic parameters were evaluated i...

Keywords

Bioavailability

Neurochemical

Tramadol Hydrochloride

In vivo

Pharmacology

Implant

Chemistry

Subcutaneous injection

Tramadol

Medicine

Analgesic

Internal medicine

Surgery

Biology

Biotechnology

Sustainable Development Goals (SDG)

Clean water and sanitation

2024

Article

Institution

Narcotics, Ergogenics and Poisons Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2024.286192.9660

Language

en

Country

Egypt

A Novel Controlled Release Subcutaneous Implant of Tramadol Hydrochloride: In Vivo Bioavailability and Neurochemical Study

Egyptian Journal of Chemistry

Shaimaa A. elshebiney, Asmaa F. Galal, Hanan Beheri, Mostafa Mabrouk

Abstract

The current study investigated the pharmacokinetic profile of a newly developed biodegradable subcutaneous tramadol implant and shed some light on neurochemical changes. Ribbons of polycaprolactone polymer were loaded with tramadol HCl in two quantities (T350, T650) and implanted in back skin of rats. Plasma tramadol levels were monitored for 45 days and pharmacokinetic parameters were evaluated i...