The dual effect of the long non coding RNA hoxa transcript at the distal tip and miR-216a on colorectal cancer

Doaa Aabdelraouf Roushdy, olfat gamil shaker, Wafaa Ghonim Shousha, Manar Seleem Fouda, Khaled Rabie Diab, Sara M. Abdo

Abstract

Background: Hoxa transcript at the distal tip (HOTTIP) plays an oncogenic role in multiple cancer types, including colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) may impact the expression and function of HOTTIP; nevertheless, limited studies have explored the correlation between HOTTIP SNP and CRC. This study aimed to assess the diagnostic performances of non-coding RNAs HOTTIP an...

Keywords

Colorectal cancer

Long non-coding RNA

microRNA

RNA

Cancer research

Biology

Internal medicine

Medicine

Cancer

Genetics

Gene

Sustainable Development Goals (SDG)

Good health and well-being

2024

Article

Institution

Faculty of Science Helwan University,

professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo,

Faculty of Medicine, Fayoum University

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2024.293873.9788

Language

en

Country

Egypt

The dual effect of the long non coding RNA hoxa transcript at the distal tip and miR-216a on colorectal cancer

Egyptian Journal of Chemistry

Doaa Aabdelraouf Roushdy, olfat gamil shaker, Wafaa Ghonim Shousha, Manar Seleem Fouda, Khaled Rabie Diab, Sara M. Abdo

Abstract

Background: Hoxa transcript at the distal tip (HOTTIP) plays an oncogenic role in multiple cancer types, including colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) may impact the expression and function of HOTTIP; nevertheless, limited studies have explored the correlation between HOTTIP SNP and CRC. This study aimed to assess the diagnostic performances of non-coding RNAs HOTTIP an...