Possible Therapeutic Effect of Chitosan Nanoparticles versus Pioglitazone Loaded Chitosan Nanoparticles on Colitis Associated with Chronic Kidney Disease in Adult Male Albino Rat Model. Histological and Biochemical Study

Rokia Mohamad Hassan, Safinaz Salah Eldin Sayed, Alaa Serag El-dean Habib, Marwa Mohamed Yousry

Abstract

Background: One of the pathogenic factors and a complication of chronic kidney disease (CKD) is colitis and intestinal dysbiosis. Pioglitazone hydrochloride (PIO), an antidiabetic medication which stimulates peroxisome proliferator-activated receptor-γ (PPAR-γ) & possess antioxidant and anti-inflammatory effects. Low aqueous solubility of PIO results in limited absorption and pharmacodynamics. The...

Keywords

Chitosan

Pioglitazone

Kidney disease

Medicine

Nanoparticle

Pharmacology

Colitis

Chemistry

Internal medicine

Materials science

Nanotechnology

Endocrinology

Diabetes mellitus

Biochemistry

Type 2 diabetes

Sustainable Development Goals (SDG)

Good health and well-being

2024

Article

Institution

Histology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Publisher

Lippincott Williams & Wilkins

2-Y Citation Average

0.158

DOI

https://doi.org/10.21608/ejh.2024.291579.2070

Language

en

Country

Egypt

Possible Therapeutic Effect of Chitosan Nanoparticles versus Pioglitazone Loaded Chitosan Nanoparticles on Colitis Associated with Chronic Kidney Disease in Adult Male Albino Rat Model. Histological and Biochemical Study

The Egyptian Journal of Histology

Rokia Mohamad Hassan, Safinaz Salah Eldin Sayed, Alaa Serag El-dean Habib, Marwa Mohamed Yousry

Abstract

Background: One of the pathogenic factors and a complication of chronic kidney disease (CKD) is colitis and intestinal dysbiosis. Pioglitazone hydrochloride (PIO), an antidiabetic medication which stimulates peroxisome proliferator-activated receptor-γ (PPAR-γ) & possess antioxidant and anti-inflammatory effects. Low aqueous solubility of PIO results in limited absorption and pharmacodynamics. The...