Gene Expression Profiling of MiRNA-190, MiRNA-588 and MiRNA-802 in Laryngeal Cancer: Diagnostic and Prognostic Values

Eman Osman, Iman El-Shabrawy, Mohamed El-Kotb, Amina Baiomy, Maha Hammad

Abstract

Laryngeal cancer (LC) is a common poor prognostic head and neck cancer. MiRNAs are promising biomarkers for diagnosis of LC. This study aims to evaluate miRNA-190, miRNA-588 and miRNA-802 expression levels and their significance as molecular biomarkers for LC. Furthermore, a prediction model for LC late stage was created to discover patients at high risk of late stage development. Quantitative rea...

Keywords

microRNA

Gene expression profiling

Gene

Biology

Gene expression

Genetics

Cancer research

Computational biology

Bioinformatics

Sustainable Development Goals (SDG)

Good health and well-being

2024

Article

Institution

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2024.267051.9274

Language

en

Country

Egypt

Gene Expression Profiling of MiRNA-190, MiRNA-588 and MiRNA-802 in Laryngeal Cancer: Diagnostic and Prognostic Values

Egyptian Journal of Chemistry

Eman Osman, Iman El-Shabrawy, Mohamed El-Kotb, Amina Baiomy, Maha Hammad

Abstract

Laryngeal cancer (LC) is a common poor prognostic head and neck cancer. MiRNAs are promising biomarkers for diagnosis of LC. This study aims to evaluate miRNA-190, miRNA-588 and miRNA-802 expression levels and their significance as molecular biomarkers for LC. Furthermore, a prediction model for LC late stage was created to discover patients at high risk of late stage development. Quantitative rea...