Glycosyl Thiourea: Synthesis, Cyclization, Reaction, Molecular Docking, and Evaluation as Potential Acetylcholinesterase Inhibitors

Salma A. Ellithy, Adel A-H Abdel-Rahman, Nasser A. Hassan, Mohamed Elsawalhy, Eman S. Abou-Amra, Allam Hassan

Citations:

1

References:

37

Abstract

In this research, we successfully synthesized a distinctive group of iminothiazolidinone derivatives, using glucose isothiocyanate as the starting material.The structural elucidation of these newly created compounds was achieved through a combination of analytical techniques, including IR, 1 H NMR, and 13 C NMR.We then evaluated the inhibitory activity of these compounds against acetylcholinestera...

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Keywords

Thiourea

Docking (animal)

Acetylcholinesterase

Glycosyl

Chemistry

Combinatorial chemistry

Stereochemistry

Enzyme

Biochemistry

Organic chemistry

Medicine

Nursing

Sustainable Development Goals (SDG)

Clean water and sanitation

2023

Article

Open Access

Institution

Department of Chemistry, Faculty of Science, Menoufia University, Shibin El-Kom 32511, Egypt.,

Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.,

Department of Photochemistry (Synthetic Unit), National Research Centre, 12622 Cairo, Egypt.,

Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.,

Department of Chemistry, Faculty of Science, Suez University, Suez 43221, Egypt.

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2023.244506.8770

Language

en

Country

Egypt,

Saudi Arabia