Fluconazole, a Fungal Cytochrome P450 Enzyme Inhibitor: The Potential Role in Augmenting Hepatotoxicity and Hyperinsulinemia Induced by Dexamethasone in Rats

Hanan Alshafeiy, Bassant M. M. Ibrahim, Marwa M. Safar, Siham M. A. El-Shenawy, Nemat A.Z. Yassin, Sanaa Kenawy

Citations:

2

References:

36

Abstract

Insulin resistance (IR) is a widespread health problem characterized by failure of cell responses to insulin. IR increases the risk of fungal infections. Long-term administration of dexamethasone is a therapeutic need accompanied IR and fungal infections. Fluconazole is the first-line antifungal therapy that inhibit fungal cytochrome P450 (CYP450) enzyme. It has a hepatotoxic effect and moderate i...

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Keywords

Fluconazole

Cytochrome P450

Dexamethasone

Hyperinsulinemia

Pharmacology

Enzyme

Cytochrome

Medicine

Internal medicine

Chemistry

Antifungal

Endocrinology

Biochemistry

Insulin

Insulin resistance

Dermatology

Sustainable Development Goals (SDG)

Good health and well-being

2019

Article

Open Access

Institution

Pharmacology Department, National Research Center, 12622, Giza, Egypt.,

Department of Pharmacology & Biochemistry, the British University in Egypt, Cairo, Egypt.,

Pharmacology Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt.

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2019.10531.1692

Language

en

Country

Egypt