Discovery and Synthesis of Novel Bio-Isostere of Purine Analogues Inhibiting SARS-CoV-2

Citations:

4

Abstract

The pathogen SARS-CoV2 is extremely infectious. The novel SARS-CoV2 (2019-nCoV) virus that causes COVID-19 is resistant to the current antiviral medications, leading to an extremely high fatality rate. Millions of people have been affected by COVID-19 worldwide, and the number is dangerously rising due to the ongoing rise in cases. Toward developing SARS-COV-2 inhibitors, many pyrimidine and purin...

Keywords

Isostere

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

Purine

2019-20 coronavirus outbreak

Drug discovery

Virology

Computational biology

Chemistry

Biology

Combinatorial chemistry

Stereochemistry

Medicine

Biochemistry

Enzyme

Infectious disease (medical specialty)

Disease

Pathology

Outbreak

2023

Article

Institution

Department of Chemistry, Faculty of Science, Helwan University, Cairo, 11795, Egypt.

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2023.196504.7681

Language

en

Country

Egypt

Discovery and Synthesis of Novel Bio-Isostere of Purine Analogues Inhibiting SARS-CoV-2

Egyptian Journal of Chemistry

Reham Mohamed-Ezzat, Galal H. Elgemeie

Citations:

4

Abstract

The pathogen SARS-CoV2 is extremely infectious. The novel SARS-CoV2 (2019-nCoV) virus that causes COVID-19 is resistant to the current antiviral medications, leading to an extremely high fatality rate. Millions of people have been affected by COVID-19 worldwide, and the number is dangerously rising due to the ongoing rise in cases. Toward developing SARS-COV-2 inhibitors, many pyrimidine and purin...