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Antitumor effect of esculetin on sorafenib -treated human hepatocellular carcinoma cell lines via suppression of VEGF-EGFR/RAS/ERK/NF-κB pathway and modulation of pI3K/ P38 axis crosstalk

Egyptian Journal of Chemistry

Islam Adel, mohamed tantawy, Ahmad Salahuddin, MAHA HOUSSEN

Keywords

Sorafenib

Crosstalk

Hepatocellular carcinoma

MAPK/ERK pathway

Hepatic carcinoma

VEGF receptors

PI3K/AKT/mTOR pathway

Cancer research

p38 mitogen-activated protein kinases

Chemistry

Medicine

Signal transduction

Physics

Biochemistry

Optics

Sustainable Development Goals (SDG)

Good health and well-being

2023

Article

Institution

Biochemistry department faculty of pharmacy Damanhour University,

Hormones Department, Medical Research Division, National Research Centre, Dokki, Giza, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2023.189470.7511

Language

Country

Antitumor effect of esculetin on sorafenib -treated human hepatocellular carcinoma cell lines via suppression of VEGF-EGFR/RAS/ERK/NF-κB pathway and modulation of pI3K/ P38 axis crosstalk

Antitumor effect of esculetin on sorafenib -treated human hepatocellular carcinoma cell lines via suppression of VEGF-EGFR/RAS/ERK/NF-κB pathway and modulation of pI3K/ P38 axis crosstalk

Egyptian Journal of Chemistry

Islam Adel, mohamed tantawy, Ahmad Salahuddin, MAHA HOUSSEN

Keywords

Sorafenib

Crosstalk

Hepatocellular carcinoma

MAPK/ERK pathway

Hepatic carcinoma

VEGF receptors

PI3K/AKT/mTOR pathway

Cancer research

p38 mitogen-activated protein kinases

Chemistry

Medicine

Signal transduction

Physics

Biochemistry

Optics

Sustainable Development Goals (SDG)

Good health and well-being

2023

Article

Institution

Biochemistry department faculty of pharmacy Damanhour University,

Hormones Department, Medical Research Division, National Research Centre, Dokki, Giza, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2023.189470.7511

Language

Country