A new series of HDAC inhibitors were designed, synthesized, bearing acyl semicarbazide, hydrazide and hydrazide derivatives as ZBGs, alkyl thio oxadiazole as the linker group and coumarin as the cap group .These derivatives were evaluated for their HDACs inhibitory activities against MDA-MB-231 (a human breast cancer cell line) and HepG2 (a human hepatocellular carcinoma cell line), most of them h...