Background and aim of the work: Idiopathic pulmonary fibrosis is a disease of unknown etiology that causes fibrosis in lung parenchyma with progressive irreversible nature with no appropriate therapy, so this study worked to evaluate the therapeutic effect of pirfenidone on a rat model of bleomycin-induced pulmonary fibrosis. Materails and methods: Thirty adult male albino rats were used in this s...