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Synthesis and antiproliferative activity of 2,4-bis(indol-3-yl)pyrrole derivatives: Marine Nortopsentin analogs

Abstract
In this study, a series of nortopsentin analogs (2,4-bis(indol-3-yl)pyrrole derivatives) were designed, synthesized, and tested for their in vitro cytotoxic activity against three cell lines: human prostate adenocarcinoma (PC-3), human ovary adenocarcinoma (SKOV3), and human Dukes' type B colorectal adenocarcinoma (LS-174T).Compounds 5a, 5e, 5h, 5j, and 5k had stronger antiproliferative activity a...
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Keywords
Pyrrole
In vitro
Adenocarcinoma
Chemistry
Stereochemistry
Doxorubicin
Cell culture
Cytotoxic T cell
Pharmacology
Biochemistry
Biology
Internal medicine
Medicine
Chemotherapy
Cancer
Organic chemistry
Genetics
Sustainable Development Goals (SDG)
Life below water


pdf file

Synthesis and antiproliferative activity of 2,4-bis(indol-3-yl)pyrrole derivatives: Marine Nortopsentin analogs
pdf file

Synthesis and antiproliferative activity of 2,4-bis(indol-3-yl)pyrrole derivatives: Marine Nortopsentin analogs

Abstract
In this study, a series of nortopsentin analogs (2,4-bis(indol-3-yl)pyrrole derivatives) were designed, synthesized, and tested for their in vitro cytotoxic activity against three cell lines: human prostate adenocarcinoma (PC-3), human ovary adenocarcinoma (SKOV3), and human Dukes' type B colorectal adenocarcinoma (LS-174T).Compounds 5a, 5e, 5h, 5j, and 5k had stronger antiproliferative activity a...
View PDF
Keywords
Pyrrole
In vitro
Adenocarcinoma
Chemistry
Stereochemistry
Doxorubicin
Cell culture
Cytotoxic T cell
Pharmacology
Biochemistry
Biology
Internal medicine
Medicine
Chemotherapy
Cancer
Organic chemistry
Genetics
Sustainable Development Goals (SDG)
Life below water


pdf file