Effect of Bone Marrow-Derived Mesenchymal Stem Cells on the Hippocampal CA1 Area of Aluminium Chloride-Induced Alzheimer's Disease in Adult Male Albino Rat: A Histological and Immunohistochemical Study.

Eman El-Beltagi, Heba ElKaliny, Khaled Moustafa, Gehan Soliman, Abd-El Moniem Zamzam

Abstract

Abstract:Background: Alzheimer’s disease (AD) is the commonest cause of dementia among the elderly. Aluminium is a toxic metal that primarily affects the hippocampus. Bone marrow-derived mesenchymal stem cells (BM-MSCs) therapy is considered a recent strategy for treatment of several diseases including neurologic disorders.Aim: To study effect of BM-MSCs on CA1 of the experimentally induced AD in ...

Keywords

Pathology

Mesenchymal stem cell

Synaptophysin

H&E stain

Immunohistochemistry

Hippocampus

Bone marrow

Hippocampal formation

Medicine

Chemistry

Endocrinology

Sustainable Development Goals (SDG)

Good health and well-being

2021

Article

Institution

Histology and Cell Biology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

Publisher

Lippincott Williams & Wilkins

2-Y Citation Average

0.158

DOI

https://doi.org/10.21608/ejh.2021.78406.1495

Language

en

Country

Egypt

Effect of Bone Marrow-Derived Mesenchymal Stem Cells on the Hippocampal CA1 Area of Aluminium Chloride-Induced Alzheimer's Disease in Adult Male Albino Rat: A Histological and Immunohistochemical Study.

The Egyptian Journal of Histology

Eman El-Beltagi, Heba ElKaliny, Khaled Moustafa, Gehan Soliman, Abd-El Moniem Zamzam

Abstract

Abstract:Background: Alzheimer’s disease (AD) is the commonest cause of dementia among the elderly. Aluminium is a toxic metal that primarily affects the hippocampus. Bone marrow-derived mesenchymal stem cells (BM-MSCs) therapy is considered a recent strategy for treatment of several diseases including neurologic disorders.Aim: To study effect of BM-MSCs on CA1 of the experimentally induced AD in ...