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Synthesis of Some 2-Substituted Quinazolin-4(3H)-one Compounds from Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate

Abstract
A series of new quinazoline-4(3H)-one derivatives (2-15) have been synthesized using methyl α-[(4-oxoquinazolin-2yl)thio]acetate (1) as precursor.The acid hydrazide (2) was synthesized via the reaction of the ester (1) with hydrazine hydrate, whereas the thiosemicarbazide (4) was synthesized either from the reaction of the acid hydrazide (2) with ammonium thiocyanate or from the reaction of the es...
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Keywords
Thio-
Chemistry
Medicinal chemistry
Stereochemistry
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file

Synthesis of Some 2-Substituted Quinazolin-4(3H)-one Compounds from Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate
pdf file

Synthesis of Some 2-Substituted Quinazolin-4(3H)-one Compounds from Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate

Abstract
A series of new quinazoline-4(3H)-one derivatives (2-15) have been synthesized using methyl α-[(4-oxoquinazolin-2yl)thio]acetate (1) as precursor.The acid hydrazide (2) was synthesized via the reaction of the ester (1) with hydrazine hydrate, whereas the thiosemicarbazide (4) was synthesized either from the reaction of the acid hydrazide (2) with ammonium thiocyanate or from the reaction of the es...
View PDF
Keywords
Thio-
Chemistry
Medicinal chemistry
Stereochemistry
Sustainable Development Goals (SDG)
Clean water and sanitation


pdf file