Synthesis, Speciation, DNA Binding, Electrochemical and Antiproliferative Properties of Pd(II) Complexes Designed to Improve the Interaction with DNA

Haneen AL-Gedany, Azza Shoukry, Saedah Al‐Mhayawi

Citations:

2

References:

36

Abstract

With the success of cisplatin, further extensive research activities resulted in the discovery of carboplatin (a second-generation drug), where the chloride is replaced by 1,1-cyclobutanedicarboxylate as a new leaving group.In the current study, we continue our previous work on the binding behavior of [Pd(byp)(H2O)2] 2+ with structural features that enhance the interaction with DNA.The coordinatio...

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Keywords

Chemistry

Intercalation (chemistry)

Cyclic voltammetry

DNA

Carboplatin

Binding constant

Adduct

Cyclobutane

Stereochemistry

Supramolecular chemistry

Crystallography

Binding site

Electrochemistry

Inorganic chemistry

Cisplatin

Ring (chemistry)

Physical chemistry

Organic chemistry

Biochemistry

Crystal structure

Electrode

Medicine

Surgery

Chemotherapy

Sustainable Development Goals (SDG)

Good health and well-being

2021

Article

Open Access

Institution

Chemistry Department, Faculty of Science, University of Jeddah, Jeddah , Kingdom of Saudi Arabia,

Department of chemistry, Faculty of Science, Cairo University

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2021.74711.3679

Language

en

Country

Saudi Arabia,

Egypt