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Chemical Synthesis of Some Novel 6-Aminouracil-2-Thiones and Their Glycoside Analogues

Abstract
AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4 a-j .The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7 a-d .The C-glycosides 8 a,b and 9 c-e were successfully prepared through condensing compound 1 and the appropriate sugar in the presence of ...
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Keywords
Chemistry
Glycoside
Stereochemistry
Combinatorial chemistry


pdf file

Chemical Synthesis of Some Novel 6-Aminouracil-2-Thiones and Their Glycoside Analogues
pdf file

Chemical Synthesis of Some Novel 6-Aminouracil-2-Thiones and Their Glycoside Analogues

Abstract
AMINOURACIL-2-THIONE (1) and its 5-bromo derivative 2 underwent alkylation yielding their respective S-alkyl products 4 a-j .The reaction of compound 1 and aldehydes in the presence of chloroacetic acid afforded the respective thiazolopyrimidinyl acetamides 7 a-d .The C-glycosides 8 a,b and 9 c-e were successfully prepared through condensing compound 1 and the appropriate sugar in the presence of ...
View PDF
Keywords
Chemistry
Glycoside
Stereochemistry
Combinatorial chemistry


pdf file