Inhibition of COVID-19 RNA-Dependent RNA Polymerase by Natural Bioactive Compounds: Molecular Docking Analysis.

Sobhy El Sohaimy, Nourhan Abdo, Mohamed Shehata, Olfat Moheyeldin

Citations:

23

References:

62

Abstract

Currently, no approved treatment for COVID-19 exists. However, phenolic compounds exhibit antiviral activity. This study aimed to evaluate the activities of polyphenolic compounds (gallic acid, quercetin, caffeine, resveratrol, naringenin, benzoic acid, oleuropein, and ellagic acid) as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (PDB ID 6M71) inhibitor...

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Keywords

Oleuropein

Gallic acid

Ellagic acid

Chemistry

Docking (animal)

AutoDock

Biochemistry

Polymerase

Naringenin

Stereochemistry

Enzyme

Polyphenol

Flavonoid

Antioxidant

Medicine

Nursing

Gene

In silico

2021

Article

Institution

1. Food Technology, City of Scientific Research and Technological Applications, Borg El Arab, Alex., Egypt. 2. Department of Technology and Orginization of Public Catering, South Ural State University, 454080 Chelyabinsh, Russia,

City of Scientific Research andTechnological Applications,

Department of Biochemistry, Faculty of Science, Alexandria University

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2021.45739.2947

Language

en

Country

Russian Federation,

Egypt