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New Pyridone, Furopyridine and Pyrazolo-pyridine Derivatives Bearing 5,6,7,8-Tetrahy-dronaphthalene Moiety: Synthesis, Antimicrobial and Genotoxicity Evaluation

Abstract
EACTION of 2-acetyl-5,6,7,8-tetrahydronaphthalene (1) with different aromatic aldehydes yielded the corresponding cyanopyridone derivatives 2a,b.Upon heating of 2a with chloroacetone, led to the formation of furopyridine derivative 4, while the reaction of compounds 2a,b with ethyl bromoacetate afforded 3-cyanopyridinyl derivatives 5a, b.Condensation of 5a,b with different amines gave the compound...
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Keywords
Moiety
Ethyl bromoacetate
Chemistry
Pyridine
Antimicrobial
Derivative (finance)
Combinatorial chemistry
Organic chemistry
Genotoxicity
Medicinal chemistry
Toxicity
Financial economics
Economics
Sustainable Development Goals (SDG)
Clean water and sanitation

2011
Article

Open Access


pdf file

New Pyridone, Furopyridine and Pyrazolo-pyridine Derivatives Bearing 5,6,7,8-Tetrahy-dronaphthalene Moiety: Synthesis, Antimicrobial and Genotoxicity Evaluation
pdf file

New Pyridone, Furopyridine and Pyrazolo-pyridine Derivatives Bearing 5,6,7,8-Tetrahy-dronaphthalene Moiety: Synthesis, Antimicrobial and Genotoxicity Evaluation

Abstract
EACTION of 2-acetyl-5,6,7,8-tetrahydronaphthalene (1) with different aromatic aldehydes yielded the corresponding cyanopyridone derivatives 2a,b.Upon heating of 2a with chloroacetone, led to the formation of furopyridine derivative 4, while the reaction of compounds 2a,b with ethyl bromoacetate afforded 3-cyanopyridinyl derivatives 5a, b.Condensation of 5a,b with different amines gave the compound...
View PDF
Keywords
Moiety
Ethyl bromoacetate
Chemistry
Pyridine
Antimicrobial
Derivative (finance)
Combinatorial chemistry
Organic chemistry
Genotoxicity
Medicinal chemistry
Toxicity
Financial economics
Economics
Sustainable Development Goals (SDG)
Clean water and sanitation

2011
Article

Open Access


pdf file