Effect of Sofosbuvir (Sovaldi) on the fundic mucosa of adult male albino rats and the possible protective role of Fucoidan: Histological, histochemical, and immunohistochemical study

Citations:

6

Abstract

Background: Sofosbuvir (SOF) is a hopeful remedy for chronic hepatitis C virus infection. However, it records some unfavorable influences on gastrointestinal tract. Fucoidan is a sulfated polysaccharide having cytoprotective effect besides anti-inflammatory and antioxidant properties.Aim: This work has been focused on the possible effect of sofosbuvir on the fundic mucosa and to assess the probabl...

Keywords

Fucoidan

Lamina propria

Sofosbuvir

Pathology

Immunohistochemistry

Cellular infiltration

Medicine

Stomach

Internal medicine

Epithelium

Hepatitis C virus

Chemistry

Virus

Polysaccharide

Immunology

Biochemistry

Inflammation

Ribavirin

2021

Article

Institution

Histology Department, Faculty of Medicine, Menoufia University, shibin el kom, egypt

Publisher

Lippincott Williams & Wilkins

2-Y Citation Average

0.158

DOI

https://doi.org/10.21608/ejh.2021.51729.1392

Language

en

Country

Egypt

Effect of Sofosbuvir (Sovaldi) on the fundic mucosa of adult male albino rats and the possible protective role of Fucoidan: Histological, histochemical, and immunohistochemical study

The Egyptian Journal of Histology

Dalia Elghazouly, Rania Yassien

Citations:

6

Abstract

Background: Sofosbuvir (SOF) is a hopeful remedy for chronic hepatitis C virus infection. However, it records some unfavorable influences on gastrointestinal tract. Fucoidan is a sulfated polysaccharide having cytoprotective effect besides anti-inflammatory and antioxidant properties.Aim: This work has been focused on the possible effect of sofosbuvir on the fundic mucosa and to assess the probabl...