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Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

Abstract
The electrochemical behavior of anti-hyperglycemic (glibenclamide, GBC) was investigated and discussed at HMDE in Britton-Robinson universal buffer using cyclic voltammetry.Its voltammogram at pH values 6-11 displayed a quasi-reversible redox couple one-electron peak corresponding to a catalytic hydrogen process.Based on this voltammetric peak, a validated and sensitive SW-AdCS voltammetric method...
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Keywords
Glibenclamide
Chemistry
Detection limit
Pharmacokinetics
Chromatography
Stripping (fiber)
Voltammetry
Redox
Electrochemistry
Pharmacology
Materials science
Electrode
Inorganic chemistry
Diabetes mellitus
Medicine
Endocrinology
Physical chemistry
Composite material


pdf file

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation
pdf file

Electro-reduction, Quantification and Pharmacokinetic Studies for the Anti-Hyperglycemic Drug Glibenclamide Using Stripping Voltammetric method: Development and Validation

Abstract
The electrochemical behavior of anti-hyperglycemic (glibenclamide, GBC) was investigated and discussed at HMDE in Britton-Robinson universal buffer using cyclic voltammetry.Its voltammogram at pH values 6-11 displayed a quasi-reversible redox couple one-electron peak corresponding to a catalytic hydrogen process.Based on this voltammetric peak, a validated and sensitive SW-AdCS voltammetric method...
View PDF
Keywords
Glibenclamide
Chemistry
Detection limit
Pharmacokinetics
Chromatography
Stripping (fiber)
Voltammetry
Redox
Electrochemistry
Pharmacology
Materials science
Electrode
Inorganic chemistry
Diabetes mellitus
Medicine
Endocrinology
Physical chemistry
Composite material


pdf file