Synthesis, Biological Evaluation and In Silico Investigation of Novel Functionalized Imidazole-Based KDM6 Inhibitors

Rabah Serya, Amr El-Araby, Omar Qassem, Ezzat El-Sawy, Eman El-Razaz, Khaled Abouzid

References:

23

Abstract

Epigenetic markers of the cellular genome are major controllers of the transcriptional level of various genes in physiological and pathological states.These markers are written and erased by epigenetic factors which have been recently studied as potential therapeutic targets of various disease states.Histone lysine demethylases (KDMs) are an example of these epigenetic factors.The histone lysine d...

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Keywords

Epigenetics

In silico

Histone

Docking (animal)

Active site

Computational biology

Biology

Imidazole

Biochemistry

Subfamily

Chemistry

Enzyme

Gene

Medicine

Nursing

Sustainable Development Goals (SDG)

Good health and well-being

2020

Article

Open Access

Institution

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.,

Professor of pharmaceutical chemistry Dean of the Faculty of Pharmacy, University of Sadat City Sadat City, Menoufia, Egypt

2-Y Citation Average

0.712

DOI

https://doi.org/10.21608/ejchem.2020.38209.2790

Language

en

Country

Egypt