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Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate
Citations:
1
References:
21
Abstract
ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate o...
Keywords
2010
Article
Open Access
2-Y Citation Average
0.712
Language
Country
Synthesis and Biological Evaluation of Some New 4(3h)-Quinazolinone Derivatives as Non-Classical Antifolate
Citations:
1
References:
21
Abstract
ALL living cell need tetrahydrofolate cofactor for the synthesis of ........ purines, some amino acid and thymidine. Most bacteria and plant produce this folate cofactor by de novo biosynthesis. Compounds that interfere with this pathway, antifolate agents have found use as anticancer. Thus, the 2-propyl-4H-3,1-benzoxazin-4-one (2) was synthesized and allowed to interaction with Ammonium acetate o...
Keywords
2010
Article
Open Access
2-Y Citation Average
0.712
Language
Country