Modulatory effect of bone marrow-derived stem cells against Tamoxifen induced liver injury in albino rats: A Histological, Immunohistochemical and Biochemical study

Abstract

Tamoxifen (TAM) is commonly used for breast cancer treatment. It is considered non-steroidal antiestrogen agent. Toxic hepatitis, significant hepatic steatosis, and cirrhosis have been reported to be caused by TAM. Stem cells (BM-MSCs) are used for regenerative medicine and therapy. Aim of the work: to know how BMMSCs can improve tamoxifen induced damage in the liver of female albino rats. Materia...

Keywords

Immunohistochemistry

Tamoxifen

Bone marrow

Medicine

Pathology

Stem cell

Bone Marrow Stem Cell

Internal medicine

Biology

Cancer

Cell biology

Breast cancer

Sustainable Development Goals (SDG)

Good health and well-being

2020

Article

Institution

histology an cell biology -faculty f medicine menoufia university

Publisher

Lippincott Williams & Wilkins

2-Y Citation Average

0.158

DOI

https://doi.org/10.21608/ejh.2020.42968.1357

Language

en

Country

Egypt

Modulatory effect of bone marrow-derived stem cells against Tamoxifen induced liver injury in albino rats: A Histological, Immunohistochemical and Biochemical study

The Egyptian Journal of Histology

seham mohammed

Abstract

Tamoxifen (TAM) is commonly used for breast cancer treatment. It is considered non-steroidal antiestrogen agent. Toxic hepatitis, significant hepatic steatosis, and cirrhosis have been reported to be caused by TAM. Stem cells (BM-MSCs) are used for regenerative medicine and therapy. Aim of the work: to know how BMMSCs can improve tamoxifen induced damage in the liver of female albino rats. Materia...