Introduction:-Pharmacology of Tramadol Tramadol Pharmacokinetics Tramadol is a synthetic opioid drug that is centrally acting.Capsules and tablets are easily available worldwide and are the most widely used formulations (Scott and Perry, 2000).After administration of oral single dose of tramadol, its bioavailability is about 70%.Its volume of distribution is nearly 306 L with plasma protein bindin...